Mechanistically, autoantibodies and interferon- present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREM to the glutathione peroxidase 4 ( Gpx4 , the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species
174 WendtK.SorkhabiM.StaggC.FlemingM.DenisonT.OSheaJ
Based on these findings, Dihexa ameliorated neuronal loss in the brains of APP/PS1 mice
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